Argyle have been drawn alongside Newport County and Swindon Town in the 21/22 Papa John's Trophy competition.
The Sky Bet League Two duo and Argyle make up three of the four teams in Group F of the southern section of the competition, with one further invited under-21 side to be announced at 4.30pm on Thursday.
It is the second consecutive season that the Pilgrims will face the Exiles in the competition, winning 3-1 at Home Park in the 20/21 campaign. We last faced Swindon Town in Papa John's Trophy action in 19/20, triumphing 3-0 at the Energy Check County Ground.
The group will be completed by one of the following clubs:
Brighton and Hove Albion
West Ham United
The Pilgrims' Carabao Cup first round opponents will also be announced on Thursday, and Argyle are ball no.26 in the southern section of the draw - which takes place at 3.40pm